Radiotherapy creates cancer stem cells 30 times more potent

Dear all,

I have been attend to Biopharma Asia 2013 in Singapore. Now, I’m in Changi airport to share a news with you. Hopefully be benefit to you.

UCLA scientists have found that radiation treatments on breast cancer cells transformed them into cancer stem cell that are far more resistant to treatment

Researchers at the Jonsson Comprehensive Cancer Center, Department of Oncology, University of California, Los Angeles (UCLA), have found that despite killing half of all tumor cells per treatment, radiation treatments on breast cancer transforms other cancer stem cells into cancer stem cells. Moreover, these cells are far more resistant to treatment as compared to cancer cells.

The new study has recently been published in the peer reviewed journal Stem Cells, Dr Frank Pajonk, senior study author and associate professor, radiation oncology, Jonsson Cancer, UCLA, said that the induced breast cancer stem cells (IBCSC) “were generated by radiation-induced activation of the same cellular pathways used to reprogram normal cells into induced pluripotent stem cells (iPS) in regenerative medicine.”

Dr Pajonk, who is also a scientist with the Eli and Edythe Brond Center of Regenerative Medicine at UCLA, added, “It was remarkable that these breast cancers used the same reprogramming pathways to fight back againts the radiation treatment.” In the new study, Dr Pajonk and his team irradiated normal non-stem cell cancer cells and placed them into mice. Through a unique imaging system, the researchers observed the cells differentiate in iBCSC in response to radiation treatments.

Dr Pajonk reported that the newly generated cells were remarkably similar to non-irradiated breast cancer stem cells. the team of researchers also found that the radiation-induced stem cells had a more than 30-fold increased ability to form tumors compared with non-irradiated breast cancer cells.


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